AFF4 and cardiomyopathy: However, many others fall into distinct, non-overlapping network modules including the ones for controlling cytokine receptor activity and cardiomyopathy in the AFF1 KD network (Figure 6D) and the ones involved the JAK-STAT cascade, protein amino acid phosphorylation, and antigen processing and presentation in the AFF4 KD network (Figure 6E).