When the GO terms (39) of the DEGs were analyzed, we found that the DEGs in AFF4 KD cells were markedly enriched in cancer-related functions including cell adhesion, angiogenesis and cell death, whereas the DEGs in response to AFF1 KD were enriched in terms associated with regulation of steroid hormone response and cellular metabolic process (Figure 6C). Here, AFF4 is linked to cancer.