Lee et al., studied the effects of a curcumin-like diarylpentanoid [2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone] in cellular targets of rheumatoid arthritis in vitro and demonstrated the compound abolished the p65 NF-κB nuclear translocation as well as binding activity of NF-κB DNA in the PMA-stimulated synovial fibroblasts via inhibited COX-2, IL-6, MMP-3, collagenase and pro-gelatinase B(pro-MMP-9) [101]. Here, NFKB1 is linked to rheumatoid arthritis.