CCL2 and neoplasm: The chemokine MCP-1 enhances recruitment of monocytes and macrophages to tumor sites [17], while the proinflammatory cytokines IL-6, IL-10, and IL-12 have diverse effects on immunity; IL-6 influences T and B cell function [18], IL-12 stimulates the growth of activated natural killer (NK) cells, and CD8+ and CD4+ T-cells [19], and IL-10 modulates monocyte and macrophage function [20].