AKT1 and leukemia: Moreover, the treatment of leukemia Molt 4 cells with different concentrations of HQ diminished the expression of p-Akt (Ser473), p-PTEN (Ser380), p-GSK3β (Ser9), p-PDK1 (Ser241) and cytosolic hexokinase II, but enhanced the expression of cytosolic hexokinase I about 1.34-fold compared to the control group at the high dose of 1.25 μg/mL (Figure 5f).