The antisense ODN is not only a useful experimental tool in protein-target identification and validation, but is also a potentially highly selective therapeutic strategy for atherosclerosis with dysregulated protein expression, as demonstrated in preclinical studies of angiotensin (Ang) II, transforming growth factor (TGF), and Janus kinase (JAK)/signal transducer and activator of transcription (STAT). Here, SOAT1 is linked to atherosclerosis.