NRG4 and Insulin resistance: Nrg4 was reported to primarily signal through the liver, where it downregulated a panel of genes involved in de novo lipogenesis, including Srebp1c, Acc1, Scd1, and Fasn. While not affecting thermogenesis, Nrg4 was shown to decrease insulin resistance and hepatosteatosis via gain-of- and loss-of-function studies in mice (63).