CCND2 and B-cell chronic lymphocytic leukemia: Due to cyclin D2 being overexpressed in freshly drawn CLL cells compared to normal B lymphocytes [22, 35, 36, 47] and maintained at similar high levels in CLL cells after 24 h of ex vivo stimulation, the median percentage of cyclin D2-positive cells in CLL patients was comparable to the corresponding cells in healthy individuals, in which up-regulation of cyclin D2 expression was observed.