Based on paper presented by Shao et al. [3], YKL-40 may not only play a role in neoangiogenesis acting as a potent angiogenic factor capable of stimulating tumor vascularization but also may induce FAK-MAPK by signaling and up-regulating VEGF receptor 2 in endothelial cells. This evidence concerns the gene CHI3L1 and neoplasm.