CHI3L1 and neoplasm: In neoangiogenesis, YKL-40—a 38-kDa glycoprotein binding heparin (gp38k) is released by the number of cells such as chondrocytes, smooth muscle cells, active neutrophils, macrophages, tumor-associated macrophages (TAM), and tumor cells, and is characterized by multidirectional activity such as involvement in the neoangiogenesis and reconstruction of extracellular matrix [2].