In MM patients with a rather hypertrophic pattern of cardiomyopathy (e.g. MELAS or MELAS-like patients), ß-blockers, angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers may potentially help to (at least) slow down the progression of cardiomyopathy – as was shown in aetiologically different forms of HCM [32]. The gene discussed is ACE; the disease is Miyoshi myopathy.