GPT and rheumatic disorder: A prospective report of Italian rheumatic disease patients found that 34/67 (50.7%) isolated HBcAb-positive patients experienced ALT elevation of ≥2 ULN at a median of 12 months after initiating TNFs in combination with nonbiologic DMARDS (methotrexate, prednisone and/or nonsteroidal anti-inflammatory drugs) [28,29].