The primed microglia blue modules (up-regulated in aged, Ercc1, App-Ps1, and Sod1 microglia) and the acute LPS-activated microglia red module (up-regulated in acute LPS activated microglia) were most strongly enriched for GOs “immune response” and “response to stress” and KEGG pathways significantly enriched in the priming blue modules were: “Alzheimer’s disease signaling”, “antigen-presentation”, “lysosome” and “phagosome”. Here, SOD1 is linked to early-onset autosomal dominant Alzheimer disease.