SOD1 and early-onset autosomal dominant Alzheimer disease: The mouse models included are: 1) aged mice; 2) accelerated aging mice (Ercc1∆/KO), a DNA repair-deficient mouse model that displays features of accelerated aging [10]; 3) APPswe/PS1dE9 (App-Ps1), a mouse model for Alzheimer’s disease, carrying transgenes for mutated Amyloid Precursor Protein and Presenilin-1 and 4) a mouse model for Amyotrophic Lateral Sclerosis (Sod193A, abbreviated as Sod1), a line carrying a mutation in the SuperOxide Dismutase-1 gene, encoding an enzyme involved in free radical degradation, resulting in motor neuron degeneration in the spinal cord [4].