This revealed that the forms of ALL with a poor outcome, which we identified as “P3”, both in children and adult patients, activate a gene group significantly overlapping hematopoietic stem cell gene expression profiles (CD133+ cells, [20]), whereas most genes involved in proliferation and cell-cycle related functions show a decreased expression as illustrated in Figure 4D (enriched and depleted gene sets listed in Supp. The gene discussed is PROM1; the disease is acute lymphoblastic leukemia.