Comparison of our previous genome wide ChIP-seq analyses of p63 function [9, 23] with microarray analyses of OPSCC [24] identified a number of p63 target genes whose expression like that of p63 (Fig. 2A) was elevated in both HPV positive, as measured by p16INK4A [p16+], and HPV negative [p16-]) oro-pharyngeal cancers compared to normal tissue [23]. This evidence concerns the gene CDKN2A and oropharynx cancer.