Piezo1 has been proposed by many to mediate a non-selective current observed in sickle cell disease (SCD) called PSickle, which acts upstream of KCa3.1 to mediate RBC sickling (Lew et al., 1997; Ranney, 1997; Ma et al., 2012; Demolombe et al., 2013). This evidence concerns the gene KCNN4 and sickle cell disease.