Our data from the mice model demonstrated that the marked decrease in body weight, mucosal bleeding induced by acute inflammation, and histologic inflammation scores were significantly recovered in the IFNA4 and IFNA10 treatment groups compared to the DSS-induce colitis controls; CD4+ CD25+ and CD4+ Foxp3+ Treg cells were also significantly increased in the IFNA subtype treatment groups compared to the control mice. Here, IFNA2 is linked to colitis.