By using CIPHER, a state-of-the-art network-based algorithm for genome-wide disease gene prediction30, we identified that IFNAR2, a receptor of IFNA4 and IFNA10, is strongly correlated with Crohn’s disease with a top rank at 65 (0.73%) among all 8919 genes (Supplementary Table 10). This evidence concerns the gene IFNA4 and Crohn disease.