As shown in Fig. 4, the total CD3+ inflammatory cells in the lamina propria were decreased, and CD4+ CD25+ and CD4+ Foxp3+ Treg cells were significantly increased in the IFNA subtype treatment groups compared to the control mice, indicating that different IFNA subtypes control acute colitis through the induction of Treg cells. The gene discussed is FOXP3; the disease is colitis.