AKT1 and neoplasm: Phosphatase and tensin homolog (PTEN) is an important tumor-suppressor gene, which is a negative regulator of the phosphatidylinositol-3-kinase (PI3K)-Akt pathway, thereby participating in the regulation of the cell cycle, proliferation, apoptosis, cell adhesion, and EMT during embryonic development and cancer progression.[11, 12].