PTEN and lip and oral cavity carcinoma: It has been reported that blockage of PI3K/Akt signaling attenuated vimentin expression in oral carcinoma cells.[31] In our study, vimentin was up-regulated in KYSE-150/RR cells (Fig 1D) and overexpression of PTEN inactivated PI3K/Akt signaling leading to downregulation of vimentin expression in these cells (Fig 1C).