ZDHHC9 and Rolandic epilepsy: The first phase of this study uncovered evidence that ZDHHC9 mutations are associated with susceptibility to focal seizures sharing features with rolandic epilepsy (RE; also known as Benign Childhood Epilepsy with CentroTemporal Spikes, BECTS), the most frequently diagnosed epilepsy syndrome of childhood.6,7 Having identified this unexpected association, we posed two targeted hypotheses.