RORC and chronic myelogenous leukemia, BCR-ABL1 positive: We also found that RORC transcript, the key transcription factor directing Th17 lineage commitment, was significantly decreased in PB or BM of ND CML patients (0.0466 ± 0.0464 or 0.3267 ± 0.0599) compared with healthy controls (0.0922 ± 0.0728 or 0.0819 ± 0.0842; *P = 0.034 or *P = 0.047).