In this study, we measured the frequencies of Th cells (Th1, Th17, and Th22), the expression of their transcription factors (RORC and AHR) and their related cytokines (IFN-γ, IL-17, and IL-22) in PB and BM of CML patients. This evidence concerns the gene RORC and chronic myelogenous leukemia, BCR-ABL1 positive.