Further, LIGHT inhibition significantly reduces OC formation from PBMCs of osteolytic MM patients and stimulates OB differentiation in cultures derived from MM bone marrow mononuclear cells, as demonstrated by the increase of colony forming units of OBs and by the upregulation of osterix transcription factor, bone sialoprotein, and osteocalcin bone matrix proteins. Here, BGLAP is linked to Miyoshi myopathy.