In 1980, Kyle and Greipp first introduce the concept of smoldering (asymptomatic) multiple myeloma (SMM) in defining six myeloma patients in whom the percentage of plasma cells and level of M protein were higher than those seen in MGUS and fulfilled the criteria for diagnosis of MM but have no anemia, hypercalcemia, and lytic bone lesions. Here, MYOM2 is linked to plasma cell myeloma.