Over time, Pèrez-Persona et al. reported that in the evolving SMM arm (defined as an increase in the level of serum M protein of at least 10% during the first 6 months of follow up, or a progressive and constant increase of the M component until overt MM developed), the 3-year progression rate for patients with aPCs/BMPC ≥ 95% was 46% versus 8% for those patients with aPCs/BMPC < 95% (P = 0.01). This evidence concerns the gene MYOM2 and Miyoshi myopathy.