In 1980, Kyle and Greipp first introduce the concept of smoldering (asymptomatic) multiple myeloma (SMM) in defining six myeloma patients in whom the percentage of plasma cells and level of M protein were higher than those seen in MGUS and fulfilled the criteria for diagnosis of MM but have no anemia, hypercalcemia, and lytic bone lesions. The gene discussed is MYOM2; the disease is Miyoshi myopathy.