Regarding regulatory T cells, TST+ healthy controls had higher Th1 : Treg ratio for Treg CD4+CD25−FoxP3+ and CD4+CD25HighFoxP3+ subpopulations than TB-active patients (P = 0.007 and P = 0.023, resp., Kruskal-Wallis test followed by Dunn's post hoc test) and Th17 : Treg ratios for all the CD4+CD25+FoxP3+ subpopulations evaluated (CD25+, P = 0.008; CD25Low, P = 0.015; and CD25High, P = 0.017, Kruskal-Wallis test followed by Dunn's post hoc test), Figures 4(b) and 4(c). The gene discussed is CD4; the disease is tuberculosis.