ANXA5 and Miyoshi myopathy: On the other hand, MM cells exposed to carfilzomib and LBH589 exhibited a much higher percentage of Annexin V+ cells (56.6% ± 8.8% for 24 h and 81.5% ± 5.0% for 48 h), indicating that the combination resulted in a significant induction of apoptosis (Figure 2).