CASP8 and Miyoshi myopathy: Our data showed that the levels of cleaved caspase-9, caspase-8, and caspase-3 were markedly increased in MM cells exposed to carfilzomib and LBH589 compared with single drug treatment, suggesting that both intrinsic (caspase-9) and extrinsic (caspase-8) apoptotic pathways were activated after combined treatment.