Ferder et al. suggested a possible feedback link between vitamin D and the renin-angiotensin system (RAS), considering that vitamin D and angiotensin II receptors are distributed in the same tissues, changes in RAA activity and activation of the vitamin D receptors seem inversely related, and vitamin D deficiency could be explained by the cellular inflammatory response activity induced by the RAA system [25]. Here, VDR is linked to vitamin D deficiency.