WEE1 and cardiac hypertrophy: A significant relationship between vitamin D level and interventricular septum and left ventricular mass index was found after adjusting for age, hypertension, and vitamin D therapy status, in a large retrospective study, suggesting the role of vitamin D in ventricular remodeling [95]. Calcium is also involved in cellular proliferation and activates AKT, a protein kinase involved in the development of cardiac hypertrophy [105].