This study describes the development of albuminuria in relation to hyperglycaemia in the diabetic E1-DN mice, a transgenic mouse model expressing kinase-negative EGF-R in pancreatic islets [31], and characterizes the pathologic changes in glomeruli including mesangial expansion and glomerular sclerosis, thickening of the GBM and widening of foot processes in albuminuric mice. Here, EGFR is linked to glomerulosclerosis.