EGFR and Glomerular sclerosis: This study describes the development of albuminuria in relation to hyperglycaemia in the diabetic E1-DN mice, a transgenic mouse model expressing kinase-negative EGF-R in pancreatic islets [31], and characterizes the pathologic changes in glomeruli including mesangial expansion and glomerular sclerosis, thickening of the GBM and widening of foot processes in albuminuric mice.