JAK2 and cancer: Other potential target genes for triptolide in a variety of cancers include caspase 3,8 and 9; XIAP; bcrabl; Bax; Bcl-2; p53; p21; NFκB; MRP-1; ERK-1/2; JNK-1/2; p38 MAPK; PI3K; 5-LOX; ADAM10; jak2; mcl-1; and histone methyltransferase (5).