Primary ovarian tumors showing high Trop2 expression, regardless of their serous or clear cell histology, are highly susceptible to hRS7-mediated antibody-dependent cellular cytotoxicity (ADCC) in the presence of effector cells in vitro. Although these tumor cells are resistant to multiple standard cytotoxic therapies in clinic studies, they remain highly sensitive to lysis by NK (natural killer) cells when these are engaged by hRS7. Here, TACSTD2 is linked to ovarian neoplasm.