Engineered professional antigen-presenting cells (APC) have been made that stimulate the growth and cytotoxicity of specific antitumor CTL in Trop2-expressing lymphomas in murine fibroblast and epithelial cell lines transfected with Tacstd2. These Trop2-specific CTL's demonstrate high specific cytotoxic properties against their transfected target, Tacstd2 [66]. The gene discussed is TACSTD2; the disease is lymphoma.