IL4 and asthma: Six studies [16–18, 21–23] reported the efficacy of acupoint application for childhood asthma on immune outcomes including immunoglobulin A (IgA), immunoglobulin E (IgE), immunoglobulin G (IgG), immunoglobulin M (IgM), interleukin-4 (IL-4), and interferon-γ (IFN-γ).