The aggregated results suggested that acupoint application showed the beneficial effect for childhood asthma in improving IgA (SMD, −0.83; 95% CI −1.14 to −0.52; P < 0.00001), IgE (SMD, −0.52; 95% CI −0.76 to −0.29; P < 0.001), IgG (SMD, −1.17; 95% CI −1.61 to −0.74; P < 0.0001), IL-4 (SMD, −0.57; 95% CI −0.91 to −0.23; P = 0.0009), and IFN-γ (SMD, −0.38; 95% CI −0.71 to −0.04; P = 0.03) but not IgM (SMD, −0.40; 95% CI −0.98 to 0.18; P = 0.18). This evidence concerns the gene CD40LG and asthma.