CXCL8 and neoplasm: After 48 hours of coculture with no direct contact of htMSCs and 4T1 tumor cells, we observed a significant increase of IL-8 (interleukin-8) and MCP-1 (monocyte chemoattractant protein-1), 44% and 37%, respectively, as well as a decrease (36%) of VEGF (vascular endothelial growth factor).