The human-angiotensinogen transgenic female mice (hAG+/+) mated with the human-renin transgenic male mice (hRN+/+) display hypertension in late pregnancy due to secretion of human renin from the fetal side into the maternal circulation and exhibit placental abnormalities, maternal cardiac hypertrophy, proteinuria, and IUGR [84, 85]. The gene discussed is REN; the disease is hypertensive disorder.