Additionally, the results of a meta-analysis investigating the risk of oral cancer in patients with polymorphisms of the IL-8-251A >T locus revealed that Caucasian populations harboring the AA genotype had a higher risk of developing malignancy (44), whereas a separate meta-analysis also indicated increased risk for individuals with either the AT or AA genotype (45). The gene discussed is CXCL8; the disease is lip and oral cavity carcinoma.