THBS2 and schistosomiasis: IgG1 is one of the main drivers of the protective humoral response to schistosomiasis (23, 24), an observation supported by studies showing that key tegument vaccine antigens like Smp80 (calpain), Sm-TSP-2, and Sm29 are the targets of these responses in schistosome-resistant individuals (32, 33, 61).