Upon conjugation to HA, water solubility of the prodrug HA-PTX, and of HYTAD1-p20 (a HA-PTX conjugate renamed as ONCOFID-P by the pharmaceutical company Fidia) significantly increased CD44 dependent cellular uptake in vitro and in vivo in cancer cells, including bladder carcinoma cells (314, 315). The gene discussed is CD44; the disease is cancer.