EGFR and cancer: In malignant colon, prostate, and breast carcinoma cells, HA-CD44 interaction activates multiple RTKs, including ERBB2, ErbB3, EGFR, IGF1R-β, PDGFR-β, and c-MET, as well as assembly of lipid-raft-integrated signaling complexes containing these activated RTKs, CD44, ezrin, PI3-kinase (PI3K) and the chaperone molecules HSP90 and CDC37, which strongly promotes apoptosis resistance in cancer cells (94, 96, 149, 228–231).