In this context, a previous study showed that activated anti-CD44 antibody (H90), when used in human acute myeloid leukemia (AML) cells, reduced the leukemic repopulation by altering the fate of AML leukocyte stem cells (AML LSC), and by abrogating AML LSC homing, leading to their death (371). The gene discussed is CD44; the disease is acute myeloid leukemia.