CD44 and neoplasm: This can be accomplished by perturbing HA-CD44 signaling pathways, by disruption of the HA matrix with HYALs to facilitate passive carrier uptake and providing a sustained source of drug at the tumor site, by targeting CD44 with a CD44-blocking antibody, or by tissue-specific targeting of specific variants of CD44v that are overexpressed in tumors (Figure 8).