HMMR and cancer: Given the crucial role that HA has in cancer cell survival, proliferation, and invasion, it is clear that HA interactions with both CD44 and RHAMM can induce numerous cell behaviors, including activation of tyrosine kinases, protein kinase C, FAK, and PI3K, MAPK, NFκB, and RAS, as well as cytoskeletal components required for inflammation and cancer (6, 24, 28, 132, 277) (model in Figure 5).