In one family, a newborn with intrauterine growth restriction presented at birth with type-1 diabetes, diarrhea, thrombocytopenia, eczematous dermatitis, eosinophilia, high IgE levels, and autoantibodies to pancreatic islet antigens at 4 days of age, with negative maternal serology. Here, IGHE is linked to type 1 diabetes mellitus.