AGER and Alzheimer disease: Lastly, the receptor for advanced glycation end-products (RAGE) plays an important role in AD by contributing to Aβ-induced neuronal dysfunction, microglial activation, and a key role in Aβ transcytosis into the brain (Yan et al., 1996, 2012; Deane et al., 2003; Origlia et al., 2008, 2010).