The relevance of miRNAs in the function of melanocortin pathways has been recently highlighted by the deletion of Dicer in POMC-expressing cells which led to a postnatal ablation of POMC neurons resulting in obesity (Schneeberger et al., 2012; Greenman et al., 2013). Here, DICER1 is linked to obesity due to melanocortin 4 receptor deficiency.