ABO and Alzheimer disease: We also showed by electron microscopy from hippocampal slices that, besides mPTP inhibition mediated by Wnt3a, this ligand can also prevent the disruption of the mitochondrial membranes and mitochondrial swelling, since the volume and size of the organelle were conserved when Wnt signaling was activated, preserving the whole structure of the mitochondria even in the presence of Aβo (Arrázola and Inestrosa, 2013), and preventing the changes that occur in AD brains during mPTP opening (Moreira et al., 2001, 2002; Du and Yan, 2010b; Du et al., 2010).