ABO and Alzheimer disease: Despite the fact that Aβ fibrils are considered as the neurotoxic species that apparently triggers AD (Hardy and Higgins, 1992; Morgan et al., 2004) both in vivo and in vitro (Alvarez et al., 2004; Dinamarca et al., 2006), currently, there is consensus that Aβo could be the main cause of AD neurotoxicity, since they are the species responsible for the synaptic dysfunction observed in this pathology (Walsh et al., 2002; Cerpa et al., 2008; Li et al., 2009).