VCAM1 and multiple sclerosis: In other context, CBD modified the deleterious effects of inflammation in a viral model of multiple sclerosis through decreasing the transmigration of blood leukocytes by downregulating the expression of vascular cell adhesion molecule-1 (VCAM-1), chemokines (CCL2 and CCL5), and the proinflammatory cytokine IL-1β [61].