TNF and acute lung injury: Additionally, CBD administration was able to decrease leukocyte migration into the lungs, myeloperoxidase activity in the lung tissue, protein concentration and production of proinflammatory cytokines (TNFα and IL-6), and chemokines (MCP-1 and MIP-2) in the bronchoalveolar lavage supernatant showing a potent anti-inflammatory effect in mice submitted to LPS-induced acute lung injury [60].