RB1 and nasopharyngeal carcinoma: Moreover, the regulatory network of genes involved in the EBV-dependent NPC reveals that NPC transformation depends timely on the regulation of DEK, CDK inhibitor, p53, RB, and several transcriptional cascades, which are interrelated by E2F, AP-1, NK-κB, and STAT3 among others during latent and lytic cycles [46].