It has been revealed that several tumor suppressor genes such as CDKN2A, ZMYND10, RASSF1, NDRG1, TACC2, and CACNA2D2 are significantly enriched within genomic regions that are frequently deleted; however, no significant correlation is established between the presence of potential tumor promoting genes and the genomic regions exhibiting gain of copy number [22]. The gene discussed is CACNA2D2; the disease is neoplasm.