According to these findings, the changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes.8,9 Some studies have indicated that, agents that increase insulin sensitivity are able to modulate the levels of these modified proteins.9 In recent years, numerous studies have been conducted on natural factors affecting diabetes including resveratrol. This evidence concerns the gene SLC2A4 and diabetes mellitus.