INS and Insulin resistance: In a study that evaluated the rosiglitazone effect on SNAREs proteins expression in hyperinsulinemia and insulin resistance status in the ZDF rat model, increased expression of these proteins was observed, while did not find significant differences in STZ-induced diabetic rats under conditions of hyperglycemia in the absence of insulin.9 Another study reported a decrease in transport and GLUT-4 content in adipose tissue of diabetic rats induced by STZ.28