CXCR4 and ovarian cancer: Signaling from CXCR4 can promote angiogenesis,25 cancer cell proliferation and metastasis to other organs.26 Anti-CXCR4 blockade antibody attenuated breast cancer cell migration27 and also decreased non-small cell lung cancer metastasis.28 Therefore, CXCR4 can be a potential target for the immunotherapy of ovarian cancer.