VTCN1 and ovarian cancer: Immunosuppressive cytokines such as IL-10, suppress immune response in ovarian tumor microenvironments through inducing several mechanisms such as B7-H4 expression on macrophages and the apoptosis of these cells.36 In ovarian cancer, this critical cytokine is not redundant with other suppressive factors and the blockade of the IL-10 signaling network leads to improved survival.37 Another study has suggested that IL-10 in combination with CA-125 may be useful in the diagnosis and also the monitoring of chemotherapy results in patients with ovarian carcinoma.