2010a). Chronically, several studies have shown that ET-A receptor blockade can attenuate the salt-induced hypertension in DS rats (Barton et al. 1998; Kassab et al. 1998; Zicha et al. 2012). Furthermore, animal models also have shown that ET-1 plays a key role mediating salt-dependent hypertension in DS rats (Kohan et al. 2011) Mattson et al. 2004; Ikeda et al. 1999). This evidence concerns the gene EDN1 and hypertensive disorder.