By identifying protein expression patterns of BIM, BCL2, BAK, and BAX as well as identifying the phosphorylation of the pro-apoptotic BAD at serine 112 (Table 2; Figure 2A), RPPA analysis helps provide a comprehensive illustration of how the anti-apoptotic characteristics of CLL are mediated among the BCL2 protein family. This evidence concerns the gene BAK1 and B-cell chronic lymphocytic leukemia.