By further analyzing our clinical RPPA dataset through differential expression analysis between CLL and healthy B-cells, we revealed upregulation of proteins that are commonly associated with CLL pathogenesis, including apoptotic resistance (e.g. BCL2 upregulation, BAX downregulation, cleaved caspase-7 downregulation) and PI3K/AKT/mTOR pathway proteins (e.g. AKT, mTOR, IRS1, GAB2, p70S6K) [29, 31, 36, 39], while also identifying overexpression of oncogenic proteins that are not well classified in CLL (e.g. BRAF, STAT5A, DVL3). Here, IRS1 is linked to B-cell chronic lymphocytic leukemia.