EIF4G1 and B-cell chronic lymphocytic leukemia: However, by treating CLL patient B-cells with the 3 inhibitors, we observed the lowest levels of the 220kDa eIF4G expression with NVP-BEZ235 treatment, while simultaneously observing increased detection of the protein fragments that correspond in size with the previously identified C-terminal fragment of apoptotic cleavage of eIF4G (C-FAG) (Figure 4C) [73, 74].