With overexpression of these AKT/mTOR-related signaling proteins, we also observed higher phosphoprotein levels for PDK1 at serine 241, 4E-BP1 at serine 65 and threonine 70, p70S6K at threonine 389, BAD at serine 112, and PRAS40 at threonine 246 in CLL samples as compared to normal donors (Figure 2A). This evidence concerns the gene AKT1 and B-cell chronic lymphocytic leukemia.