In fact, based on log-fold/rank comparison of all probes represented in the RPPA panel, eIF4G overexpression is the most upregulated protein event in our CLL cohorts, whereas the pro-apoptotic protein events Annexin I expression and cleaved-caspase 7 are the most downregulated events in CLL [28-31] (Figure 1C). Here, ANXA1 is linked to B-cell chronic lymphocytic leukemia.