EIF4G1 and B-cell chronic lymphocytic leukemia: Based on our corresponding results that demonstrate the overexpression of eIF4G, the phosphorylation of 4E-BP1, and the subsequent reversal of both events in NVP-BEZ235-mediated CLL apoptosis, we provide further insight into the potential interplay between mRNA translation activation and CLL survival as well as demonstrate a proper strategy for effectively targeting this aberrant molecular mechanism in CLL.