To help determine the specific molecular mechanisms that are altered in CLL, we interrogated the total proteins from the differentially expressed probes in the RPPA dataset and observed overrepresentation of signaling events regulating the PI3K/AKT pathway, with pathways specifically involved in the mRNA translation machinery of eukaryotic cells (Figure 2B, Supplementary File S2). The gene discussed is AKT1; the disease is B-cell chronic lymphocytic leukemia.