CD38 and B-cell chronic lymphocytic leukemia: Along with discovering these single gene prognostic markers in CLL, genome-wide DNA methylation and gene expression studies have also demonstrated genomic signatures that correspond with specific CLL subtypes, like IGVH mutation and CD38 expression status and have provided better comprehension of the molecular abnormalities that occur in this disease [3, 8, 11, 12, 15-17].