Finally, we collectively compared the semi-quantitative 4E-BP1 phosphorylation and eIF4G cleavage levels with the Annexin V+/DAPI+ cells in each treatment and determined that greater apoptotic induction corresponds with greater 4E-BP1 dephosphorylation and eIF4G cleavage, suggesting that attenuating the protein events that upregulate translational initiation can impede cell survival mechanisms in CLL (Figure 4D). Here, ANXA5 is linked to B-cell chronic lymphocytic leukemia.