Regarding as the relationship among Wnt6, Wnt7b and Wnt11, the noncanonical Wnt signaling, and tumorigenesis, Galbraith RL et al have reported that the polymorphisms in Wnt6 was associated with increased risk of colorectal adenoma [39], suggesting that Wnt6 may involve in tumorigenesis by initiating the noncanonical Wnt signaling. The gene discussed is WNT7B; the disease is colorectal adenoma.