Kaplan-Meier survival analysis illustrates inferior DFS for young, but not older, patients with the HER2-enriched breast cancer over-expressing KRT6A and KRT6B. Taken together, this data suggests that the keratin genes may be involved in young adult cancers- beyond that of the basal subtype - and that overexpression of these genes may negatively impact outcome for women with young adult breast cancer. This evidence concerns the gene ERBB2 and breast cancer.