BLf has been reported to up-regulate the sensitivity of extrinsic pathway death receptor Fas as well as inducing caspase-3 and −8 cleavage in colon cancer models [22, 23] Results from the same studies also indicated up-regulation of pro-apoptotic Bcl-2 family genes Bax and Bid. The gene discussed is CASP3; the disease is colonic neoplasm.