Moreover, The study in in T47D and HS578D breast cancer cell lines [21], was performed with native bLf (15-20% Fe3+ saturated), thus the dosage level difference could be due to the modification of iron saturation levels of bLf given that the work we have performed is with Apo-bLf (iron free) and Fe-bLf (iron saturated). The gene discussed is AOPEP; the disease is breast cancer.