More recently, we have reported that native bLf downregulates survivin gene expression in SW480 colon cancer cells [7], and Fe-bLf nanoformulation targets survivin to kill colon cancer stem cells [41] Here however it was found that MDA-MB-231 cells showed highly significant decreases in survivin protein expression levels, as well as strong increases in IAP inhibitors SMAC/DIABLO and HTRA2. Here, BIRC5 is linked to malignant colon neoplasm.