ANXA5 and rheumatoid arthritis: In addition, the number of annexin V-positive and propidium iodide (PI)-negative RA-FLS, which indicated cells in the apoptotic stage, was higher, and the number of live cells (annexin V and PI-double negative) was lower in the cells transfected with siRNA 2B than those transfected with siRNA control (Fig. 4g–i).