NRP1 and neoplasm: Moreover, through H&E staining and NRP1 immunohistochemistry, we found that the tumour formed by Inh-148b cells injection showed more tube formation and NRP1 overexpression, as well as excessive cell division and increased nucleo-cytoplasmic ratio, whereas the tumour formed by miR-148b cells injection showed the opposite effects (Figure 7B), indicating that miR-148b might regulate the tumorigenesis by inhibit the expression of NRP1 and further reduce the formation of SP cells with CSC-like properties.