On the other hand, the loss of the expression of caspase-1 (interleukin-1β converting enzyme), a member of the cysteine protease family, is observed in 19.3% of cases of gastric cancer and this loss in its expression is reversed by treatment with 5-aza-2′-deoxycytidine and/or trichostatin in gastric cancer cell lines (52). Here, CTSB is linked to gastric cancer.