Using these approaches, we identified eight miRNAs (miR-218, miR-19a, miR-19b, miR-148a, miR-148b, miR-152, miR-30a, miR-30d) that could potentially bind to complementary sequences in the SOCS3 3’-UTR .We next examined the expression of these miRNAs in inflamed intestinal mucosa from active CD patients by TaqMan probe-based qRT-PCR. This evidence concerns the gene SOCS3 and Cowden disease.