In normoxic conditions, vemurafenib treatment of the melanoma cell line 518A2 resulted in a decreased protein expression level of pERK1/2 (Thr202/Tyr204) (Fig. 6B) and decreased expression levels of pFAK (Tyr397), FAK and AKT compared to untreated 518A2 cells (Fig. 6A). Here, PTK2 is linked to melanoma.